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Lornoxicam
- Short-term relief of acute mild to moderate pain.
- Symptomatic relief of pain and inflammation in:
- Osteoarthritis.
- Rheumatoid arthritis.
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✅ Description:
- Inhibits prostaglandin synthesis by blocking the cyclooxygenase (COX) enzyme.
- Reduces peripheral nociceptor sensitivity, alleviating pain and inflammation.
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✔️ Side Effects
- Common:
- Gastrointestinal issues: Peptic ulcers, nausea, vomiting, diarrhea, constipation, abdominal pain, dyspepsia.
- Severe (rare):
- Gastrointestinal bleeding or perforation, especially in the elderly.
- Exacerbation of colitis or Crohn’s disease.
- Dizziness or vision disturbances.
✔️ Dosage & Administration
Adults:
- Acute Pain:
- 8–16 mg daily, divided into 2–3 doses.
- Maximum dose: 16 mg/day.
- Osteoarthritis/Rheumatoid Arthritis:
- Initial dose: 12 mg daily, divided into 2–3 doses.
- Maintenance dose: Maximum 16 mg/day.
Children & Adolescents:
- Not recommended for those under 18 due to insufficient safety and efficacy data.
Elderly (above 65):
- No specific dosage adjustment is required but use cautiously due to the higher risk of gastrointestinal side effects.
Renal Impairment:
- Mild to moderate impairment: Maximum 12 mg/day, divided into 2–3 doses.
Hepatic Impairment:
- Moderate impairment: Maximum 12 mg/day, divided into 2–3 doses.
- Use the lowest effective dose for the shortest duration.
✔️ Overdose Effects
- Symptoms: Nausea, vomiting, dizziness, and visual disturbances.
- Management: Withdraw medication, and consider gastric lavage.
- No specific antidote; emergency measures should be taken.
- Lornoxicam has a short half-life and is not dialyzable.
✔️ Interactions
- Increased bleeding risk: With Vitamin K antagonists (e.g., warfarin).
- Reduced kidney function: With cyclosporine (rarely leads to acute kidney injury).
- Increased adverse effects: With lithium, methotrexate, and digoxin.
- Reduced efficacy: Diuretics, ACE inhibitors, and angiotensin II receptor antagonists in heart failure patients.
✔️ Contraindications
- Hypersensitivity to Lornoxicam or its excipients.
- Peptic ulcer or severe gastrointestinal conditions.
- Severe hepatic or renal impairment.
- Thrombocytopenia.
- Third trimester of pregnancy.
✔️ Pregnancy & Lactation
- Contraindicated in the third trimester of pregnancy.
- Avoid this in the first and second trimesters due to the lack of safety data.
- Avoid breastfeeding as Lornoxicam is excreted in rat milk, though human data is unavailable.
✔️ Use cautiously in:
- Impaired kidney function.
- History of gastrointestinal bleeding, hypertension, or heart failure.
- Conditions like ulcerative colitis, Crohn’s disease, or SLE (Systemic Lupus Erythematosus).
- Avoid women undergoing infertility treatment.
✔️ Storage Conditions
- Store below 30°C, protected from light and moisture.
- Keep out of the reach of children.
Disclaimer:
ePharma sole intention is to ensure that its consumers get proper
information as musch as possible. Although we do not guarantee the
accuracy and the completeness of the information that provided and
here information is for informational purposes only.
The information contained herein should NOT be used as a substitute
for the advice of a qualified physician. This may not cover
everything about particular health conditions,
lab tests, medicines, all possible side effects, drug interactions,
warnings, alerts, etc. Please consult your healthcare professional
and discuss all your queries related to any disease or medicine. We
intend to support, not replace, the doctor-patient relationship.
